Do Zinc and Vitamin C Reduce COVID symptoms? | Medscape

F. Perry Wilson, MD, MSCE


February 17, 2021

This was a 2 x 2 factorial design, as you can see here. Patients were randomized to usual care or to one of the three treatment arms in a roughly equal fashion.

But when you stratify by treatment, the time to 50% symptom reduction was basically the same across the board: about 5.5 to 6.5 days, depending.

No individual symptom resolved quicker with zinc, vitamin C, or the combo. Basically, the population looked like we’ve come to expect: a few days of fever, with lingering cough and fatigue.

Hospitalization rate didn’t significantly differ, though it was slightly higher in the supplement groups. And there were thankfully only three deaths — one in the vitamin C group and two in the combo group.

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